The Future of Fentanyl and Other Synthetic Opioids

RAND Policy Labs

Past event

Aug 28, 2025

12:00 – 1:00 p.m. ET Online

Registration Closed

Since 2013, illegally manufactured fentanyl has been linked to approximately 450,000 drug overdose deaths in the United States. Recent data suggest that these deaths are declining, but new threats are emerging—including dangerous adulterants like fentanyl mixed with xylazine and even more potent synthetic opioids such as nitazenes. What actions might be taken to confront this evolving crisis, and what new policy solutions could help turn the tide?

A purple ribbon tied around a tree in Victoria Park to recognize International Overdose Awareness Day, in Edmonton, Alberta, Canada, August 31, 2023

Photo by Artur Widak/NurPhoto via Reuters