This report examines the wider impacts of eight Health Research Board (HRB)-funded grants from the early and mid-1990s. These impacts are identified using a case study approach, built on the payback framework for research evaluation. The report then considers the economic repercussions of these wider impacts. The report presents the historical context of health research funding in Ireland, which has undergone major changes in last 20 years. It then goes on to identify the economic impacts arising from the case studies, provides summaries for all eight case studies and places the findings in the rapidly developing context of Irish health research. Finally, it presents a way for the HRB to take this methodology forward and implement it in its own evaluation programme.